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Yasuhiko Tomino Selected Research

Immunoglobulin A (IgA)

11/2017Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy.
12/2016Diagnosis and treatment of patients with IgA nephropathy in Japan.
3/2015TWEAK/Fn14 system and crescent formation in IgA nephropathy.
1/2015Pathogenic Role of a Proliferation-Inducing Ligand (APRIL) in Murine IgA Nephropathy.
10/2014Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy.
6/2014Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.
6/2014Proposal of remission criteria for IgA nephropathy.
2/2014Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes.
1/2014A panel of serum biomarkers differentiates IgA nephropathy from other renal diseases.
1/2014Development of Animal Models of Human IgA Nephropathy.
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Yasuhiko Tomino Research Topics

Disease

63IGA Glomerulonephritis (IGA Nephropathy)
10/2018 - 08/2002
48Proteinuria
12/2018 - 01/2002
38Diabetic Nephropathies (Diabetic Nephropathy)
02/2021 - 01/2002
20Glomerulonephritis
01/2019 - 08/2002
18Chronic Renal Insufficiency
12/2018 - 09/2003
17Chronic Kidney Failure (Chronic Renal Failure)
01/2019 - 01/2002
16Hypertension (High Blood Pressure)
12/2016 - 09/2003
15Hematuria
12/2017 - 01/2003
15Inflammation (Inflammations)
01/2017 - 03/2005
13Peritoneal Fibrosis
01/2021 - 05/2004
13Albuminuria
05/2018 - 12/2003
13Fibrosis (Cirrhosis)
01/2015 - 07/2002
10Nephrosis
01/2018 - 12/2000
10Nephrotic Syndrome (Syndrome, Nephrotic)
12/2017 - 04/2004
9Body Weight (Weight, Body)
10/2014 - 09/2003
9Infections
02/2014 - 11/2003
9Type 2 Diabetes Mellitus (MODY)
01/2014 - 12/2002
8Renal Insufficiency (Renal Failure)
02/2021 - 06/2002
7Peritonitis
01/2021 - 06/2003
7Hyperglycemia
05/2015 - 01/2002
7Disease Progression
02/2014 - 03/2008
5Anemia
11/2020 - 05/2012
5Kidney Diseases (Kidney Disease)
12/2017 - 09/2005
5Nephritis
07/2013 - 12/2000
5Sclerosis
09/2012 - 07/2002
5Insulin Resistance
01/2012 - 01/2004
5Glucose Intolerance
07/2009 - 11/2004
4Membranous Glomerulonephritis (Membranous Nephropathy)
12/2017 - 08/2002
4Dyslipidemias (Dyslipidemia)
05/2015 - 08/2005
4Hypertrophy
04/2014 - 01/2002
4Lupus Nephritis
01/2014 - 03/2002
4Atherosclerosis
01/2014 - 01/2008
4Vasculitis (Vasculitides)
08/2010 - 08/2008
4Wounds and Injuries (Trauma)
01/2007 - 01/2002
3Hereditary Angioedemas
08/2021 - 10/2017
3Arteriovenous Fistula
04/2017 - 09/2012
3Schizophrenia (Dementia Praecox)
01/2017 - 04/2015
3Diabetes Mellitus
09/2015 - 11/2003

Drug/Important Bio-Agent (IBA)

36Immunoglobulin A (IgA)IBA
11/2017 - 08/2002
32Proteins (Proteins, Gene)FDA Link
12/2016 - 01/2002
29CreatinineIBA
02/2021 - 01/2002
18AlbuminsIBA
02/2021 - 07/2002
18Antigen-Antibody Complex (Immune Complex)IBA
01/2019 - 03/2003
14SteroidsIBA
01/2019 - 06/2004
14Biomarkers (Surrogate Marker)IBA
01/2017 - 01/2003
10galactosyl-deficient IgA1IBA
11/2017 - 01/2007
8Polysaccharides (Glycans)IBA
11/2017 - 01/2007
7Immunoglobulin G (IgG)IBA
01/2019 - 11/2005
7Complement System Proteins (Complement)IBA
01/2014 - 08/2010
6Glucose (Dextrose)FDA LinkGeneric
01/2021 - 01/2002
6Advanced Glycation End ProductsIBA
04/2015 - 08/2005
6Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA
11/2011 - 01/2002
6Angiotensin Receptor AntagonistsIBA
01/2011 - 09/2003
6Triglycerides (Triacylglycerol)IBA
01/2010 - 08/2005
6Blood Glucose (Blood Sugar)IBA
07/2009 - 11/2003
5Immunoglobulins (Immunoglobulin)IBA
05/2021 - 02/2010
5Dialysis SolutionsIBA
01/2021 - 06/2007
5Uric Acid (Urate)IBA
01/2020 - 01/2010
5AntibodiesIBA
10/2018 - 01/2007
5Galactose (Galactopyranose)FDA LinkGeneric
10/2018 - 01/2007
5Doxorubicin (Adriamycin)FDA LinkGeneric
01/2018 - 01/2011
5Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
12/2017 - 08/2013
5Puromycin AminonucleosideIBA
05/2015 - 12/2000
5CytokinesIBA
02/2014 - 01/2007
5Adrenal Cortex Hormones (Corticosteroids)IBA
12/2013 - 10/2004
5Angiotensin IIIBA
10/2013 - 12/2004
5Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
06/2012 - 08/2008
5Immunosuppressive Agents (Immunosuppressants)IBA
06/2010 - 10/2004
5Collagen Type IV (Type IV Collagen)IBA
01/2005 - 01/2002
4LigandsIBA
04/2017 - 10/2002
4CalciumIBA
09/2015 - 10/2004
4LectinsIBA
08/2015 - 03/2005
4Reactive Oxygen Species (Oxygen Radicals)IBA
05/2015 - 06/2011
4Hemoglobins (Hemoglobin)IBA
10/2014 - 05/2008
4Transforming Growth Factors (Transforming Growth Factor)IBA
08/2012 - 06/2005
4PyridoxamineIBA
01/2012 - 02/2007
4Mannose-Binding Lectin (Mannan-Binding Lectin)IBA
01/2012 - 03/2005
4Calcium Channel Blockers (Blockers, Calcium Channel)IBA
11/2011 - 09/2003
4Transforming Growth Factor beta (TGF-beta)IBA
11/2011 - 06/2005
4antiglomerular basement membrane antibodyIBA
11/2011 - 03/2008
4Glycated Hemoglobin (Glycosylated Hemoglobin)IBA
01/2010 - 01/2002
3IronIBA
04/2022 - 01/2014
3IndicanIBA
11/2018 - 07/2002
3AST 120IBA
11/2018 - 07/2002
3mizoribineIBA
12/2017 - 06/2004
3Type II Tumor Necrosis Factor ReceptorsIBA
12/2017 - 01/2015
3Type I Tumor Necrosis Factor ReceptorsIBA
12/2017 - 01/2015
3Prednisolone (Predate)FDA LinkGeneric
12/2017 - 12/2009
3Toll-Like Receptor 9IBA
04/2017 - 12/2008
3pentosidineIBA
01/2017 - 08/2008
3NPHS2 proteinIBA
01/2017 - 01/2015
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2017 - 06/2010
3ErythropoietinFDA Link
12/2016 - 04/2014
3ReninIBA
12/2016 - 10/2002
3Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
05/2015 - 01/2002

Therapy/Procedure

33Therapeutics
01/2019 - 09/2003
23Renal Dialysis (Hemodialysis)
10/2020 - 06/2002
12Tonsillectomy
10/2018 - 01/2007
10Peritoneal Dialysis
10/2015 - 01/2004
3Transplantation
10/2014 - 02/2013